Timeline
The ideas behind AI_PREMie came into being in 2015 when University College Dublin colleagues, Professor Patricia Maguire and Professor Fionnuala Ní Áinle, met for a coffee.
An Irish Times article from 2021 documented this meeting:
...Ní Áinle talked about her experiences as a consultant haematologist at the Rotunda, seeing women with severe pre-eclampsia. They discussed the potential for biomarkers in the blood to serve as an early warning system and went on to confirm this with a study showing significant differences in the platelets of pregnant women suspected of having pre-eclampsia and healthy women of the same age. Armed with this evidence and a large amount of related data, the team was able to take its research to the next level when it applied for Science Foundation Ireland’s AI for Societal Good Challenge funding. Using an interdisciplinary approach, it could unlock new insights with data analytics and machine learning techniques.
Explore the timeline of developments since the AI_PREMie project’s inception.
AI_PREMie featured in the SASsoftware and Microsoft joint whitepaper highlighting co-developed clinical decision support tools enabled by advanced analytics and AI in the cloud.
Professor Patricia Maguire discusses the AI_PREMie PET diagnosis tool with Pat Kenny.
Listen on Spotify.
AI_PREMie won awards in both categories that it was nominated for:
1). Best Application of AI to Achieve Social Good
2). Best Application of AI in an Academic Research Body.
Challenge funding is playing a key role in honing research projects across Ireland, according to researchers, including AI_PREMie.
The AI_PREMie team attended the ISTH2022 (the 30th Congress of the International Society on Thrombosis and Haemostasis) in London, UK.
AI_PREMie was honoured to be nominated for the Social Impact Award at the Analytics and AI Awards 22.
Professor Patrica Maguire discusses the AI_PREMie PET diagnosis tool.
AI_PREMie launched a campaign for World Preeclampsia Day to highlight this life-threatening disease and also promote the work done by the AI_PREMie team to develop a diagnostic tool for preeclampsia.
Research Impact Case Study Competition - runner up.
The Irish Universities Association has partnered with RTÉ and New Decade TV to bring Ireland’s Change Makers, the most transformative research-led projects and the inspiring people behind them, to Irish television this coming January and February 2022.
The series will showcase the remarkable and lasting public impact of leading research projects by eight universities in Ireland in areas such as children’s health, health technology, education, youth justice, gender equality and inclusion, as well as the environment.
Patricia Maguire spoke to Newstalk Radio's Late Breakfast presenter Shane Beatty about her preeclampsia research, ahead of the RTE TV show Change Makers which features her AI_PREMie project.
On this episode, Greg speaks with Professor Patricia Maguire, Biomedical Scientist and Director of University College Dublin’s Institute for Discovery. Maguire’s research focuses on platelets, an interest that began 25 years ago when her father suffered his first heart attack and she recognized the need for better diagnostics in the clinic.
Researchers Are Discovering How to Predict – and Maybe Treat — Pregnancy Complications Early On.
Improving Maternal Health through AI and Biomedical Science | Health Pulse Podcast
"Using platelets as little health sensors in our blood" - The Irish Times.
"Using platelets as little health sensors in our blood" - Recruitment for Technology
Winner of the NovaUCD Innovation of the Year Award 2021.
AI_PREMie: A Novel Risk Stratification Tool for Preeclamptic-toxaemia
SFI AI for Societal Good Challenge
Supports interdisciplinary teams to develop novel, potentially disruptive AI-based solutions that address significant national and global societal challenges.
Read more on SFI.
Upon activation platelets release a host of soluble and vesicular signals, collectively termed the ‘platelet releasate’ (PR). The contents of this PR play a significant role in haemostasis, wound healing, tissue regeneration, inflammation, and pathologic sequelae.
Read the full article on Science Direct.
Read the full article in Proteomics Clinical Applications.
Upon activation, platelets release a powerful cocktail of soluble and vesicular signals, collectively termed the "platelet releasate" (PR). Although several studies have used qualitative/quantitative proteomic approaches to characterize PR; with debated content and significant inter-individual variability reported, confident, and reliable insights have been hindered. Using label-free quantitative (LFQ)-proteomics analysis, a reproducible, quantifiable investigation of the 1U mL−1 thrombin-induced PR from 32 healthy adults was conducted.
Read the full article in Proteomics.
Retrospective secondary analysis of an observational study in an Irish tertiary referral centre with 9000 deliveries annually. The MPV of 27 women with EOPE was compared to 19 unaffected controls. The inclusion criteria for the disease state was the development of EOPE defined by the National Institute for Health and Care Excellence (NICE) guideline, as new onset hypertension presenting after 20 weeks and prior to 34 weeks with significant proteinuria.
Read the full article in the Journal of Perinatal Medicine.
Early onset preeclampsia (EOP) is a pregnancy-specific proinflammatory disorder that is characterised by competing thrombotic and bleeding risks. It was the aim of this study to characterise thrombin generation, a major determinant of thrombotic and bleeding risk, in order to better understand the haemostatic balance in patients with EOP.
Read the full article on PubMed.
