AIPREMIE

Publications

A selection of publications on the diverse research by the transdisciplinary AI_PREMie team, including healthcare and AI experts, industry partners, and business leaders.

2024

Weiss L, Uhrig W, Kelliher S, Szklanna PB, Prendiville T, Comer SP, Edebiri O, Egan K, Lennon Á, Kevane B, Murphy S, Ní Áinle F, Maguire PB. Proteomic analysis of extracellular vesicle cargoes mirror the cardioprotective effects of rivaroxaban in patients with venous thromboembolism. Proteomics Clin Appl. 2024 Jan 9:e2300014. https://doi.org/10.1002/prca.202300014

2023

O’Reilly D, Murphy CA, Moore CM, Ní Áinle F, Gormley IC, Morrell CN, Curley A, Mc Callion N, Maguire P. Markers of platelet activation foR identification of late onset sEpsis in infaNTs: PARENT study protocol. Pediatr Res. 2023 Sep 27. doi: 10.1038/s41390-023-02812-x. Epub ahead of print. PMID: 37758864. https://doi.org/10.1038/s41390-023-02812-x

Kelliher S, Gamba S, Weiss L, Shen Z, Marchetti M, Schieppati F, Scaife C, Madden S, Bennett K, Fortune A, Maung S, Fay M, Ní Áinle F, Maguire P, Falanga A, Kevane B, Krishnan A. Platelet proteo-transcriptomic profiling validates mediators of thrombosis and proteostasis in patients with myeloproliferative neoplasms. bioRxiv. 2023 Oct 26:2023.10.23.563619. https://www.biorxiv.org/content/10.1101/2023.10.23.563619v2

Sigle M, Rohlfing AK, Kenny M, Scheuermann S, Sun N, Graeßner U, Haug V, Sudmann J, Seitz CM, Heinzmann D, Schenke-Layland K, Maguire PB, Walch A, Marzi J, Gawaz MP. Translating genomic tools to Raman spectroscopy analysis enables high-dimensional tissue characterization on molecular resolution. Nat Commun. 2023 Sep 19;14(1):5799. https://www.nature.com/articles/s41467-023-41417-0

Nikčević AV, Sacchi C, Marino C, O’Gorman N, Poon LC, Nicolaides KH. Psychological Impact and Women’s Evaluation of the First-Trimester Pre-Eclampsia Screening and Prevention: ASPRE Trial. Int J Environ Res Public Health. 2023 Apr 6;20(7):5418. https://doi.org/10.3390/ijerph20075418

Creswell L, O’Gorman N, Palmer KR, da Silva Costa F, Rolnik DL. Perspectives on the Use of Placental Growth Factor (PlGF) in the Prediction and Diagnosis of Pre-Eclampsia: Recent Insights and Future Steps. Int J Womens Health. 2023 Feb 13;15:255-271. https://doi.org/10.2147/IJWH.S368454

Weiss L, MacLeod H, Comer SP, Cullivan S, Szklanna PB, Ní Áinle F, Kevane B, Maguire PB. An optimized protocol to isolate quiescent washed platelets from human whole blood and generate platelet releasate under clinical conditions. STAR Protoc. 2023 Apr 18;4(2):102150. https://doi.org/10.1016/j.xpro.2023.102150

Schönichen C, Montague SJ, Brouns SLN, Burston JJ, Cosemans JMEM, Jurk K, Kehrel BE, Koenen RR, Ní Áinle F, O’Donnell VB, Soehnlein O, Watson SP, Kuijpers MJE, Heemskerk JWM, Nagy M. Antagonistic Roles of Human Platelet Integrin αIIbβ3 and Chemokines in Regulating Neutrophil Activation and Fate on Arterial Thrombi Under Flow. Arterioscler Thromb Vasc Biol. 2023 Sep;43(9):1700-1712. https://doi.org/10.1161/ATVBAHA.122.318767

Contursi A, Fullone R, Szklanna-Koszalinska P, Marcone S, Lanuti P, Taus F, Meneguzzi A, Turri G, Dovizio M, Bruno A, Pedrazzani C, Tacconelli S, Marchisio M, Ballerini P, Minuz P, Maguire P, Patrignani P. Tumor-Educated Platelet Extracellular Vesicles: Proteomic Profiling and Crosstalk with Colorectal Cancer Cells. Cancers (Basel). 2023 Jan 5;15(2):350. https://doi.org/10.3390/cancers15020350

Smyth S, Mulligan K, Rutter E, Harrington L, Hatunic M, Higgins MF. Attitudes of women with gestational diabetes toward diet and exercise: a qualitative study. J Matern Fetal Neonatal Med. 2023 Dec;36(1):2155045. doi: 10.1080/14767058.2022.2155045. PMID: 36599434. https://doi.org/10.1080/14767058.2022.2155045

2022

Saeed K, Ní Ainle F: Commentary on “Bleeding Complications in Women with Venous Thromboembolism during Pregnancy: A Systematic Review of the Literature”. Res Pract Thromb Haemost. 25 October 2022 https://doi.org/10.1002/rth2.12822

Wright D, Tan MY, O’Gorman N, Syngelaki A, Nicolaides KH. Serum PlGF compared with PAPP-A in first trimester screening for preterm pre-eclampsia: Adjusting for the effect of aspirin treatment. BJOG. 2022 Jul;129(8):1308-1317. doi: 10.1111/1471-0528.17096. Epub 2022 Feb 13. PMID: 35015330. https://doi.org/10.1111/1471-0528.17099.

Edebiri O, Ní Áinle F. Risk factors, diagnosis and management of venous thromboembolic disease in pregnancy. Breathe (Sheff). 2022 Jun;18(2):220018. doi: 10.1183/20734735.0018-2022. Epub 2022 Jul 12. PMID: 36337136; PMCID: PMC9584596. https://breathe.ersjournals.com/content/18/2/220018

Raia-Barjat T, Edebiri O, Ni Ainle F. Preeclampsia and Venous Thromboembolism: Pathophysiology and Potential Therapy. Front Cardiovasc Med. 2022 Mar 7;9:856923. doi: 10.3389/fcvm.2022.856923. PMID: 35345482; PMCID: PMC8957069. https://doi.org/10.3389/fcvm.2022.856923

Kelliher S, Weiss L, Cullivan S, O’Rourke E, Murphy CA, Toolan S, Lennon Á, Szklanna PB, Comer SP, Macleod H, Le Chevillier A, Gaine S, O’Reilly KMA, McCullagh B, Stack J, Maguire PB, Ní Áinle F, Kevane B. Non-severe COVID-19 is associated with endothelial damage and hypercoagulability despite pharmacological thromboprophylaxis. J Thromb Haemost. 2022 Apr;20(4):1008-1014. doi: 10.1111/jth.15660. Epub 2022 Feb 13. PMID: 35102689; PMCID: PMC9305123. https://doi.org/10.1111/jth.15660

Rohlfing AK, Kolb K, Sigle M, Ziegler M, Bild A, Münzer P, Sudmann J, Dicenta V, Harm T, Manke MC, Geue S, Kremser M, Chatterjee M, Liang C, von Eysmondt H, Dandekar T, Heinzmann D, Günter M, von Ungern-Sternberg S, Büttcher M, Castor T, Mencl S, Langhauser F, Sies K, Ashour D, Beker MC, Lämmerhofer M, Autenrieth SE, Schäffer TE, Laufer S, Szklanna P, Maguire P, Heikenwalder M, Müller KAL, Hermann DM, Kilic E, Stumm R, Ramos G, Kleinschnitz C, Borst O, Langer HF, Rath D, Gawaz M. ACKR3 regulates platelet activation and ischemia-reperfusion tissue injury. Nat Commun. 2022 Apr 5;13(1):1823. doi: 10.1038/s41467-022-29341-1. PMID: 35383158; PMCID: PMC8983782. https://www.nature.com/articles/s41467-022-29341-1

O’Reilly D, Murphy CA, Drew R, El-Khuffash A, Maguire PB, Ainle FN, Mc Callion N. Platelets in pediatric and neonatal sepsis: novel mediators of the inflammatory cascade. Pediatr Res. 2022 Jan;91(2):359-367. doi: 10.1038/s41390-021-01715-z. Epub 2021 Oct 28. PMID: 34711945; PMCID: PMC8816726. https://www.nature.com/articles/s41390-021-01715-z

Comer SP, Le Chevillier A, Szklanna PB, Kelliher S, Saeed K, Cullen S, Edebiri O, O’Neill T, Stephens N, Weiss L, Murphy CA, Rajakumar S, Tierney A, Hughes C, Lennon Á, Moran N, Maguire PB, Ní Áinle F, Kevane B. Case Report: Hypergranular Platelets in Vaccine-Induced Thrombotic Thrombocytopenia After ChAdOx1 nCov-19 Vaccination. Front Cardiovasc Med. 2022 Feb 9;9:824601. doi: 10.3389/fcvm.2022.824601. PMID: 35224056; PMCID: PMC8865139. https://doi.org/10.3389/fcvm.2022.824601

Murphy CA, Neary E, O’Reilly DP, Cullivan S, El-Khuffash A, NíAinle F, Maguire PB, McCallion N, Kevane B. The role of the calibrated automated thrombogram in neonates: describing mechanisms of neonatal haemostasis and evaluating haemostatic drugs. Eur J Pediatr. 2022 Jan;181(1):23-33. doi: 10.1007/s00431-021-04196-8. Epub 2021 Jul 20. PMID: 34283272; PMCID: PMC8760221. https://link.springer.com/article/10.1007/s00431-021-04196-8

Neary E, Murphy CA, Ní Áinle F, El-Khuffash A, Cotter M, Kirkham C, McCallion N “Plasma transfusion to prevent intraventricular haemorrhage in very preterm infants (CD012341)”. Cochrane Database Syst Rev. 2016 Sep 22;2016(9):CD012341. doi: 10.1002/14651858.CD012341. PMCID: PMC6470970. https://doi.org/10.1002/14651858.CD012341

Keating N, Coveney C, McAuliffe FM, Higgins MF. Aerobic or Resistance Exercise for Improved Glycaemic Control and Pregnancy Outcomes in Women with Gestational Diabetes Mellitus: A Systematic Review. Int J Environ Res Public Health. 2022 Aug 30;19(17):10791. doi: 10.3390/ijerph191710791. PMID: 36078508; PMCID: PMC9518565. https://doi.org/10.3390/ijerph191710791

Shahid A, Bazargani MH, Banahan P, Mac Namee B, Kechadi T, Treacy C, Regan G, MacMahon P. A Two-Stage De-Identification Process for Privacy-Preserving Medical Image Analysis. Healthcare (Basel). 2022 Apr 19;10(5):755. doi: 10.3390/healthcare10050755. PMID: 35627892; PMCID: PMC9141493. https://doi.org/10.3390/healthcare10050755

Doyle GA, O’Donnell S, Cullen K, Quigley E, Gibney S; Diabetes Literacy Consortium. Understanding the cost of care of type 2 diabetes mellitus – a value measurement perspective. BMJ Open. 2022 Jan 13;12(1):e053001. doi: 10.1136/bmjopen-2021-053001. PMID: 35027420; PMCID: PMC8762124. https://bmjopen.bmj.com/content/12/1/e053001

2021

Szklanna PB, Whoriskey S,  Rajakumar S, Curran J,  MacNamee B,  Donnelly J, O’Gorman N, Higgins M,  Ní Áinle F,  Maguire PB, P-001. AI_PREMie: A novel risk stratification tool for preeclamptic-toxaemia, Pregnancy Hypertension, Volume 25, Supplement 1, 2021, Page e29, ISSN 2210-7789 (https://www.sciencedirect.com/science/article/pii/S2210778921001100)

Murphy CA, O’Reilly DP, Edebiri O, Weiss L, Cullivan S, El-Khuffash A, Doyle E, Donnelly JC, Malone FD, Ferguson W, Drew RJ, O’Loughlin J, Neary E, Maguire PB, Kevane B, NíAinle F, McCallion N. Haematological parameters and coagulation in umbilical cord blood following COVID-19 infection in pregnancy. Eur J Obstet Gynecol Reprod Biol. 2021 Nov;266:99-105. doi: 10.1016/j.ejogrb.2021.09.019. Epub 2021 Sep 21. PMID: 34601263; PMCID: PMC8454187. https://doi.org/10.1016/j.ejogrb.2021.09.019

Weiss L, Keaney J, Szklanna PB, Prendiville T, Uhrig W, Wynne K, Kelliher S, Ewins K, Comer SP, Egan K, O’Rourke E, Moran E, Petrov G, Patel A, Lennon Á, Blanco A, Kevane B, Murphy S, Ní Áinle F, Maguire PB. Nonvalvular atrial fibrillation patients anticoagulated with rivaroxaban compared with warfarin exhibit reduced circulating extracellular vesicles with attenuated pro-inflammatory protein signatures. J Thromb Haemost. 2021 Oct;19(10):2583-2595. doi: 10.1111/jth.15434. Epub 2021 Jul 16. PMID: 34161660. https://doi.org/10.1111/jth.15434

Szklanna PB, Altaie H, Comer SP, Cullivan S, Kelliher S, Weiss L, Curran J, Dowling E, O’Reilly KMA, Cotter AG, Marsh B, Gaine S, Power N, Lennon Á, McCullagh B, Ní Áinle F, Kevane B, Maguire PB. Routine Hematological Parameters May Be Predictors of COVID-19 Severity. Front Med (Lausanne). 2021 Jul 16;8:682843. doi: 10.3389/fmed.2021.682843. PMID: 34336889; PMCID: PMC8322583 https://doi.org/10.3389/fmed.2021.682843

Comer SP, Cullivan S, Szklanna PB, Weiss L, Cullen S, Kelliher S, Smolenski A, Murphy C, Altaie H, Curran J, O’Reilly K, Cotter AG, Marsh B, Gaine S, Mallon P, McCullagh B, Moran N, Ní Áinle F, Kevane B, Maguire PB; COCOON Study investigators. COVID-19 induces a hyperactive phenotype in circulating platelets. PLoS Biol. 2021 Feb 17;19(2):e3001109. doi: 10.1371/journal.pbio.3001109. PMID: 33596198; PMCID: PMC7920383 https://doi.org/10.1371/journal.pbio.3001109

Cullivan S, Murphy CA, Weiss L, Comer SP, Kevane B, McCullagh B, Maguire PB, Ní Ainle F, Gaine SP. Platelets, extracellular vesicles and coagulation in pulmonary arterial hypertension. Pulm Circ. 2021 Jun 4;11(3):20458940211021036. doi: 10.1177/20458940211021036. PMID: 34158919; PMCID: PMC8182202. https://doi.org/10.1177/20458940211021036

Twomey L, Navasiolava N, Robin A, Bareille MP, Gauquelin-Koch G, Beck A, Larcher F, Meade-Murphy G, Sheridan S, Maguire PB, Harrison M, Degryse B, Moyna NM, Gharib C, Custaud MA, Murphy RP. A dry immersion model of microgravity modulates platelet phenotype, miRNA signature, and circulating plasma protein biomarker profile. Sci Rep. 2021 Nov 9;11(1):21906. doi: 10.1038/s41598-021-01335-x. PMID: 34753989; PMCID: PMC8578674. https://doi.org/10.1038/s41598-021-01335-x

Keating NE, Dempsey B, Corcoran S, McAuliffe FM, Lalor J, Higgins MF. Women’s experience of pregnancy and birth during the COVID-19 pandemic: a qualitative study. Ir J Med Sci. 2022 Oct;191(5):2177-2184. doi: 10.1007/s11845-021-02862-2. Epub 2021 Dec 2. PMID: 34855128; PMCID: PMC8636585. https://doi.org/10.1007/s11845-021-02862-2

Alghamdi E, Rushe E, Mac Namee B, Greene D. Overlapping community finding with noisy pairwise constraints. Appl Netw Sci. 2020;5(1):98. doi: 10.1007/s41109-020-00340-9. Epub 2020 Dec 11. PMID: 33344759; PMCID: PMC7732810. https://doi.org/10.1007/s41109-020-00340-9

Jing M, Ng KY, Namee BM, Biglarbeigi P, Brisk R, Bond R, Finlay D, McLaughlin J. COVID-19 modelling by time-varying transmission rate associated with mobility trend of driving via Apple Maps. J Biomed Inform. 2021 Oct;122:103905. doi: 10.1016/j.jbi.2021.103905. Epub 2021 Sep 2. PMID: 34481056; PMCID: PMC8410221. https://doi.org/10.1016/j.jbi.2021.103905

Filos D, Lekka I, Kilintzis V, Stefanopoulos L, Karavidopoulou Y, Maramis C, Diou C, Sarafis I, Papapanagiotou V, Alagialoglou L, Ioakeimidis I, Hassapidou M, Charmandari E, Heimeier R, O’Malley G, O’Donnell S, Doyle G, Delopoulos A, Maglaveras N. Exploring Associations Between Children’s Obesogenic Behaviors and the Local Environment Using Big Data: Development and Evaluation of the Obesity Prevention Dashboard. JMIR Mhealth Uhealth. 2021 Jul 9;9(7):e26290. doi: 10.2196/26290. PMID: 34048353; PMCID: PMC8274675. https://mhealth.jmir.org/2021/7/e26290

O’Dwyer V, Russell NM, McDonnell B, Sharkey L, Mulcahy C, Higgins MF. Antenatal prediction of fetal macrosomia in pregnancies affected by maternal pre-gestational diabetes. J Matern Fetal Neonatal Med. 2022 Dec;35(25):7412-7416. doi: 10.1080/14767058.2021.1949447. Epub 2021 Jul 6. PMID: 34229553. https://doi.org/10.1080/14767058.2021.1949447

Schinckus L, Van den Broucke S, van der Zanden G, Levin-Zamir D, Mueller G, Riemenschneider H, Hayter V, Yardley L, Schillinger D, Doyle G, Ganahl K, Pelikan J, Chang P. To Adapt or Not to Adapt: The Association between Implementation Fidelity and the Effectiveness of Diabetes Self-Management Education. Int J Environ Res Public Health. 2021 Apr 13;18(8):4095. doi: 10.3390/ijerph18084095. PMID: 33924494; PMCID: PMC8069177. https://doi.org/10.3390/ijerph18084095

2020

Kelliher S, Maguire PB, Szklanna PB, Weiss L, Ewins K, O’Doherty R, Angelov D, Ní Áinle F, Kevane B. Pathophysiology of the Venous Thromboembolism Risk in Preeclampsia. Hamostaseologie. 2020 Dec;40(5):594-604. doi: 10.1055/a-1162-3905. Epub 2020 May 25. PMID: 32450576. https://www.thieme-connect.de/products/ejournals/abstract/10.1055/a-1162-3905

Murphy CA, O’Reilly DP, Neary E, El-Khuffash A, NíAinle F, McCallion N, Maguire PB. A review of the role of extracellular vesicles in neonatal physiology and pathology. Pediatr Res. 2021 Aug;90(2):289-299. doi: 10.1038/s41390-020-01240-5. Epub 2020 Nov 12. PMID: 33184501. https://doi.org/10.1038/s41390-020-01240-5

Cremer SE, Catalfamo JL, Goggs R, Seemann SE, Kristensen AT, Szklanna PB, Maguire PB, Brooks MB. The canine activated platelet secretome (CAPS): A translational model of thrombin-evoked platelet activation response. Res Pract Thromb Haemost. 2020 Dec 3;5(1):55-68. doi: 10.1002/rth2.12450. PMID: 33537530; PMCID: PMC7845059. https://doi.org/10.1002/rth2.12450

Skeith L, Blondon M, Ní Áinle F. Understanding and Preventing Placenta-Mediated Pregnancy Complications. Hamostaseologie. 2020 Aug;40(3):356-363. doi: 10.1055/a-1184-8388. Epub 2020 Jul 29. PMID: 32726830. https://www.thieme-connect.com/products/ejournals/abstract/10.1055/a-1184-8388

Maguire PB, Parsons ME, Szklanna PB, Zdanyte M, Münzer P, Chatterjee M, Wynne K, Rath D, Comer SP, Hayden M, Ní Áinle F, Gawaz M. Comparative Platelet Releasate Proteomic Profiling of Acute Coronary Syndrome versus Stable Coronary Artery Disease. Front Cardiovasc Med. 2020 Jun 24;7:101. doi: 10.3389/fcvm.2020.00101. PMID: 32671099; PMCID: PMC7328343. https://doi.org/10.3389/fcvm.2020.00101

Keogh A, Johnston W, Ashton M, Sett N, Mullan R, Donnelly S, Dorn JF, Calvo F, Mac Namee B, Caulfield B. “It’s Not as Simple as Just Looking at One Chart”: A Qualitative Study Exploring Clinician’s Opinions on Various Visualisation Strategies to Represent Longitudinal Actigraphy Data. Digit Biomark. 2020 Nov 26;4(Suppl 1):87-99. doi: 10.1159/000512044. PMID: 33442583; PMCID: PMC7768127. https://doi.org/10.1159/000512044

O’Donnell S, Doyle G, O’Malley G, Browne S, O’Connor J, Mars M, Kechadi MM. Establishing consensus on key public health indicators for the monitoring and evaluating childhood obesity interventions: a Delphi panel study. BMC Public Health. 2020 Nov 17;20(1):1733. doi: 10.1186/s12889-020-09814-y. PMID: 33203390; PMCID: PMC7670696. https://doi.org/10.1186/s12889-020-09814-y

Bartels HC, Mulligan KM, Lalor JG, Higgins MF, Brennan DJ. A life changing experience: An interpretative phenomenological analysis of women’s experiences of placenta accreta spectrum. Eur J Obstet Gynecol Reprod Biol. 2020 Nov;254:102-108. doi: 10.1016/j.ejogrb.2020.09.014. Epub 2020 Sep 13. PMID: 32950888. https://doi.org/10.1016/j.ejogrb.2020.09.014

Gibney S, Bruton L, Ryan C, Doyle G, Rowlands G. Increasing Health Literacy May Reduce Health Inequalities: Evidence from a National Population Survey in Ireland. Int J Environ Res Public Health. 2020 Aug 13;17(16):5891. doi: 10.3390/ijerph17165891. PMID: 32823744; PMCID: PMC7459493. https://doi.org/10.3390/ijerph17165891

Browne S, Kechadi MT, O’Donnell S, Dow M, Tully L, Doyle G, O’Malley G. Mobile Health Apps in Pediatric Obesity Treatment: Process Outcomes From a Feasibility Study of a Multicomponent Intervention. JMIR Mhealth Uhealth. 2020 Jul 8;8(7):e16925. doi: 10.2196/16925. PMID: 32673267; PMCID: PMC7381070. https://doi.org/10.3390/ijerph17165891

Hunter E, Namee BM, Kelleher JD. A Model for the Spread of Infectious Diseases in a Region. Int J Environ Res Public Health. 2020 Apr 30;17(9):3119. doi: 10.3390/ijerph17093119. PMID: 32365775; PMCID: PMC7246727. https://doi.org/10.3390/ijerph17093119

2019

Haire G, Egan K, Parmar K, McKinnon T, Monteith C, O’Connor H, Kevane B, Maguire P, Szklanna PB, Galligan M, Donnelly JC, Allen S, McCallion N, Hunt B, Áinle FN. Alterations in fibrin formation and fibrinolysis in early onset-preeclampsia: Association with disease severity. Eur J Obstet Gynecol Reprod Biol. 2019 Oct;241:19-23. doi: 10.1016/j.ejogrb.2019.07.035. Epub 2019 Jul 25. PMID: 31415952. https://doi.org/10.1016/j.ejogrb.2019.07.035

Nikčević AV, Dodd Z, Prior J, O’Gorman N, Poon LC, Nicolaides KH. Reasons for accepting or declining participation in the ASPRE trial: A qualitative study with women at high risk of preterm pre-eclampsia. Prenat Diagn. 2019 Nov;39(12):1127-1135. doi: 10.1002/pd.5554. Epub 2019 Sep 13. PMID: 31479510. https://doi.org/10.1002/pd.5554

van der Pol LM, Tromeur C, Bistervels IM, Ni Ainle F, van Bemmel T, Bertoletti L, Couturaud F, van Dooren YPA, Elias A, Faber LM, Hofstee HMA, van der Hulle T, Kruip MJHA, Maignan M, Mairuhu ATA, Middeldorp S, Nijkeuter M, Roy PM, Sanchez O, Schmidt J, Ten Wolde M, Klok FA, Huisman MV; Artemis Study Investigators. Pregnancy-Adapted YEARS Algorithm for Diagnosis of Suspected Pulmonary Embolism. N Engl J Med. 2019 Mar 21;380(12):1139-1149. doi: 10.1056/NEJMoa1813865. PMID: 30893534 https://www.nejm.org/doi/full/10.1056/NEJMoa1813865

O’Shaughnessy F, Donnelly JC, Bennett K, Damkier P, Áinle FN, Cleary BJ. Prevalence of postpartum venous thromboembolism risk factors in an Irish urban obstetric population. J Thromb Haemost. 2019 Nov;17(11):1875-1885. doi: 10.1111/jth.14568. Epub 2019 Sep 10. PMID: 31309719. https://doi.org/10.1111/jth.14568

Grande R, Dovizio M, Marcone S, Szklanna PB, Bruno A, Ebhardt HA, Cassidy H, Ní Áinle F, Caprodossi A, Lanuti P, Marchisio M, Mingrone G, Maguire PB, Patrignani P. Platelet-Derived Microparticles From Obese Individuals: Characterization of Number, Size, Proteomics, and Crosstalk With Cancer and Endothelial Cells. Front Pharmacol. 2019 Jan 22;10:7. doi: 10.3389/fphar.2019.00007. PMID: 30723407; PMCID: PMC6349702. https://doi.org/10.3389/fphar.2019.00007

Brefeld U, Curry E, Daly E, Macnamee B, Marascu A, Pinelli F. Foreword to applied data science, demo, and nectar tracks. 1 Jan 2019 Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)11053 LNAI:V-VI https://doi.org/10.1007/978-3-030-10997-4

2018

Szklanna PB, Parsons ME, Wynne K, O’Connor H, Egan K, Allen S, Ní Áinle F, Maguire PB. The Platelet Releasate is Altered in Human Pregnancy. Proteomics Clin Appl. 2019 May;13(3):e1800162. doi: 10.1002/prca.201800162. Epub 2018 Oct 29. PMID: 30318839. https://doi.org/10.1002/prca.201800162

Parsons MEM, Szklanna PB, Guerrero JA, Wynne K, Dervin F, O’Connell K, Allen S, Egan K, Bennett C, McGuigan C, Gheveart C, Ní Áinle F, Maguire PB. Platelet Releasate Proteome Profiling Reveals a Core Set of Proteins with Low Variance between Healthy Adults. Proteomics. 2018 Aug;18(15):e1800219. doi: 10.1002/pmic.201800219. Epub 2018 Jul 15. PMID: 29932309. https://doi.org/10.1002/pmic.201800219

Maguire PB, Donlon T, Parsons M, Wynne K, Dillon E, Ní Áinle F, Szklanna PB. Proteomic Analysis Reveals a Strong Association of β-Catenin With Cadherin Adherens Junctions in Resting Human Platelets. Proteomics. 2018 May;18(9):e1700419. doi: 10.1002/pmic.201700419. PMID: 29510447. https://doi.org/10.1002/pmic.201700419

Wright D, Tan MY, O’Gorman N, Poon LC, Syngelaki A, Wright A, Nicolaides KH. Predictive performance of the competing risk model in screening for preeclampsia. Am J Obstet Gynecol. 2019 Feb;220(2):199.e1-199.e13. doi: 10.1016/j.ajog.2018.11.1087. Epub 2018 Nov 14. Erratum in: Am J Obstet Gynecol. 2019 Apr 24;: PMID: 30447210. https://doi.org/10.1016/j.ajog.2018.11.1087

2017

Parsons ME, O’Connell K, Allen S, Egan K, Szklanna PB, McGuigan C, Ní Áinle F, Maguire PB. Thrombin generation correlates with disease duration in multiple sclerosis (MS): Novel insights into the MS-associated prothrombotic state. Mult Scler J Exp Transl Clin. 2017 Dec 26;3(4):2055217317747624. doi: 10.1177/2055217317747624. PMID: 29318029; PMCID: PMC5753921. https://doi.org/10.1177/2055217317747624

Parsons MEM, McParland D, Szklanna PB, Guang MHZ, O’Connell K, O’Connor HD, McGuigan C, Ní Áinle F, McCann A, Maguire PB. A Protocol for Improved Precision and Increased Confidence in Nanoparticle Tracking Analysis Concentration Measurements between 50 and 120 nm in Biological Fluids. Front Cardiovasc Med. 2017 Nov 3;4:68. doi: 10.3389/fcvm.2017.00068. PMID: 29164135; PMCID: PMC5675884. https://doi.org/10.3389/fcvm.2017.00068

O’Shaughnessy F, Donnelly JC, Cooley SM, Deering M, Raman A, Gannon G, Hickey J, Holland A, Hayes N, Bennett K, Ní Áinle F, Cleary BJ. Thrombocalc: implementation and uptake of personalized postpartum venous thromboembolism risk assessment in a high-throughput obstetric environment. Acta Obstet Gynecol Scand. 2017 Nov;96(11):1382-1390. doi: 10.1111/aogs.13206. Epub 2017 Sep 21. PMID: 28832906. https://doi.org/10.1111/aogs.13206

Rolnik DL, Wright D, Poon LC, O’Gorman N, Syngelaki A, de Paco Matallana C, Akolekar R, Cicero S, Janga D, Singh M, Molina FS, Persico N, Jani JC, Plasencia W, Papaioannou G, Tenenbaum-Gavish K, Meiri H, Gizurarson S, Maclagan K, Nicolaides KH. Aspirin versus Placebo in Pregnancies at High Risk for Preterm Preeclampsia. N Engl J Med. 2017 Aug 17;377(7):613-622. doi: 10.1056/NEJMoa1704559. Epub 2017 Jun 28. PMID: 28657417. https://www.nejm.org/doi/full/10.1056/NEJMoa1704559

Egan K, O’Connor H, Kevane B, Malone F, Lennon A, Al Zadjali A, Cooley S, Monteith C, Maguire P, Szklanna PB, Allen S, McCallion N, Ní Áinle F. Elevated plasma TFPI activity causes attenuated TF-dependent thrombin generation in early onset preeclampsia. Thromb Haemost. 2017 Jul 26;117(8):1549-1557. doi: 10.1160/TH16-12-0949. Epub 2017 Jun 1. PMID: 28569919. https://www.thieme-connect.com/products/ejournals/abstract/10.1160/TH16-12-0949

Kevane B, Egan K, Allen S, Maguire P, Neary E, Lennon Á, Ní Áinle F. Endothelial barrier protective properties of low molecular weight heparin: A novel potential tool in the prevention of cancer metastasis? Res Pract Thromb Haemost. 2017 Jun 20;1(1):23-32. doi: 10.1002/rth2.12011. PMID: 30046671; PMCID: PMC5974908 https://doi.org/10.1002/rth2.12011

Szklanna PB, Wynne K, Nolan M, Egan K, Áinle FN, Maguire PB. Comparative proteomic analysis of trophoblast cell models reveals their differential phenotypes, potential uses, and limitations. Proteomics. 2017 May;17(10):e1700037. doi: 10.1002/pmic.201700037. PMID: 28317260. https://doi.org/10.1002/pmic.201700037

Vajen T, Benedikter BJ, Heinzmann ACA, Vasina EM, Henskens Y, Parsons M, Maguire PB, Stassen FR, Heemskerk JWM, Schurgers LJ, Koenen RR. Platelet extracellular vesicles induce a pro-inflammatory smooth muscle cell phenotype. J Extracell Vesicles. 2017 May 16;6(1):1322454. doi: 10.1080/20013078.2017.1322454. PMID: 28717419; PMCID: PMC5505004. https://doi.org/10.1080/20013078.2017.1322454

McDonnell BP, Glennon K, McTiernan A, O’Connor HD, Kirkham C, Kevane B, Donnelly JC, Ni Áinle F. Adjustment of therapeutic LMWH to achieve specific target anti-FXa activity does not affect outcomes in pregnant patients with venous thromboembolism. J Thromb Thrombolysis. 2017 Jan;43(1):105-111. doi: 10.1007/s11239-016-1409-5. PMID: 27517381. https://doi.org/10.1007/s11239-016-1409-5

2016

Szklanna PB, Foy M, Wynne K, Byrne D, Maguire PB. Analysis of the proteins associated with platelet detergent resistant membranes. Proteomics. 2016 Sep;16(17):2345-50. doi: 10.1002/pmic.201500309. PMID: 27329341. https://doi.org/10.1002/pmic.201500309

O’Gorman N, Wright D, Rolnik DL, Nicolaides KH, Poon LC. Study protocol for the randomised controlled trial: combined multimarker screening and randomised patient treatment with ASpirin for evidence-based PREeclampsia prevention (ASPRE). BMJ Open. 2016 Jun 28;6(6):e011801. doi: 10.1136/bmjopen-2016-011801. PMID: 27354081; PMCID: PMC4932292 https://bmjopen.bmj.com/content/6/6/e011801

O’Gorman N, Nicolaides KH, Poon LC. The use of ultrasound and other markers for early detection of preeclampsia. Womens Health (Lond). 2016;12(2):199-207. doi: 10.2217/whe.15.95. Epub 2016 Feb 22. PMID: 26900911; PMCID: PMC5375054. https://doi.org/10.2217/whe.15.95

2015

O’Gorman N, Wright D, Syngelaki A, Akolekar R, Wright A, Poon LC, Nicolaides KH. Competing risks model in screening for preeclampsia by maternal factors and biomarkers at 11-13 weeks gestation. Am J Obstet Gynecol. 2016 Jan;214(1):103.e1-103.e12. doi: 10.1016/j.ajog.2015.08.034. Epub 2015 Aug 19. PMID: 26297382. https://doi.org/10.1016/j.ajog.2015.08.034

Egan K, Kevane B, Ní Áinle F. Elevated venous thromboembolism risk in preeclampsia: molecular mechanisms and clinical impact. Biochem Soc Trans. 2015 Aug;43(4):696-701. doi: 10.1042/BST20140310. Epub 2015 Aug 3. PMID: 26551715. https://doi.org/10.1042/bst20140310

Kelleher JD, MacNamee B, DArcy A. Fundamentals of Machine Learning for Predictive Data Analytics: Algorithms, Worked Examples, and Case Studies 2015 Fundamentals of Machine Learning for Predictive Data Analytics: Algorithms, Worked Examples and Case Studies 1-595 https://onesearch.library.rice.edu/permalink/01RICE_INST/i8rmhu/alma991010767719705251

2014

Kevane B, Donnelly J, D’Alton M, Cooley S, Preston RJ, Ní Ainle F. Risk factors for pregnancy-associated venous thromboembolism: a review. J Perinat Med. 2014 Jul;42(4):417-25. doi: 10.1515/jpm-2013-0207. PMID: 24334422. https://doi.org/10.1515/jpm-2013-0207

2013

Corcoran D, Murphy D, Donnelly JC, Ainle FN. The prevalence of maternal F cells in a pregnant population and potential overestimation of foeto-maternal haemorrhage as a consequence. Blood Transfus. 2014 Oct;12(4):570-4. doi: 10.2450/2014.0297-13. Epub 2013 Jun 12. PMID: 24960639; PMCID: PMC4212039. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4212039/

Donnelly JC, Cooley SM, Walsh TA, Smith OP, Gillan J, McMahon C, Geary MP. Circulating pro- and anticoagulant levels in normal and complicated primigravid pregnancies and their relationship to placental pathology. J Obstet Gynaecol. 2013 Apr;33(3):264-8. doi: 10.3109/01443615.2012.758694. PMID: 23550854. https://doi.org/10.3109/01443615.2012.758694

Donnelly JC, Cooley SM, Doyle A, Murphy D, Corcoran D, Kumpel B, Ní Ainle F. False positive Kleihauer-Betke (acid elution) test caused by elevated maternal fetal haemoglobin F cells. Eur J Obstet Gynecol Reprod Biol. 2014 Jan;172:136-7. doi: 10.1016/j.ejogrb.2013.10.012. Epub 2013 Oct 17. PMID: 24192664. https://doi.org/10.1016/j.ejogrb.2013.10.012

2012

Macaulay IC, Thon JN, Tijssen MR, Steele BM, MacDonald BT, Meade G, Burns P, Rendon A, Salunkhe V, Murphy RP, Bennett C, Watkins NA, He X, Fitzgerald DJ, Italiano JE Jr, Maguire PB. Canonical Wnt signaling in megakaryocytes regulates proplatelet formation. Blood. 2013 Jan 3;121(1):188-96. doi: 10.1182/blood-2012-03-416875. Epub 2012 Nov 16. PMID: 23160460; PMCID: PMC3538329. https://doi.org/10.1182/blood-2012-03-416875

Steele BM, Harper MT, Smolenski AP, Alkazemi N, Poole AW, Fitzgerald DJ, Maguire PB. WNT-3a modulates platelet function by regulating small GTPase activity. FEBS Lett. 2012 Jul 30;586(16):2267-72. doi: 10.1016/j.febslet.2012.05.060. Epub 2012 Jun 13. PMID: 22705156. https://doi.org/10.1016/j.febslet.2012.05.060

2011

Johnston O, Cassidy H, O’Connell S, O’Riordan A, Gallagher W, Maguire PB, Wynne K, Cagney G, Ryan MP, Conlon PJ, McMorrow T. Identification of β2-microglobulin as a urinary biomarker for chronic allograft nephropathy using proteomic methods. Proteomics Clin Appl. 2011 Aug;5(7-8):422-31. doi: 10.1002/prca.201000160. Epub 2011 Jul 13. PMID: 21751411. https://doi.org/10.1002/prca.201000160

2010

Goodall AH, Burns P, Salles I, Macaulay IC, Jones CI, Ardissino D, de Bono B, Bray SL, Deckmyn H, Dudbridge F, Fitzgerald DJ, Garner SF, Gusnanto A, Koch K, Langford C, O’Connor MN, Rice CM, Stemple D, Stephens J, Trip MD, Zwaginga JJ, Samani NJ, Watkins NA, Maguire PB, Ouwehand WH; Bloodomics Consortium. Transcription profiling in human platelets reveals LRRFIP1 as a novel protein regulating platelet function. Blood. 2010 Nov 25;116(22):4646-56. doi: 10.1182/blood-2010-04-280925. Epub 2010 Sep 10. PMID: 20833976; PMCID: PMC2996120. https://doi.org/10.1182/blood-2010-04-280925

2009

Steele BM, Harper MT, Macaulay IC, Morrell CN, Perez-Tamayo A, Foy M, Habas R, Poole AW, Fitzgerald DJ, Maguire PB. Canonical Wnt signaling negatively regulates platelet function. Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):19836-41. doi: 10.1073/pnas.0906268106. Epub 2009 Nov 9. PMID: 19901330; PMCID: PMC2785253 https://doi.org/10.1073/pnas.0906268106

2007

Behan AT, Foy M, Wynne K, Clarke M, Sullivan M, Cotter DR, Maguire PB. Analysis of membrane microdomain-associated proteins in the insular cortex of post-mortem human brain. Proteomics Clin Appl. 2007 Oct;1(10):1324-31. doi: 10.1002/prca.200700047. Epub 2007 Sep 10. PMID: 21136629. https://doi.org/10.1002/prca.200700047

Coppinger JA, O’Connor R, Wynne K, Flanagan M, Sullivan M, Maguire PB, Fitzgerald DJ, Cagney G. Moderation of the platelet releasate response by aspirin. Blood. 2007 Jun 1;109(11):4786-92. doi: 10.1182/blood-2006-07-038539. Epub 2007 Feb 15. PMID: 17303692. https://doi.org/10.1182/blood-2006-07-038539

Foy M, Harney DF, Wynne K, Maguire PB. Enrichment of phosphotyrosine proteome of human platelets by immunoprecipitation. Methods Mol Biol. 2007;357:313-8. doi: 10.1385/1-59745-214-9:313. PMID: 17172697. https://doi.org/10.1385/1-59745-214-9:313

Coppinger J, Fitzgerald DJ, Maguire PB. Isolation of the platelet releasate. Methods Mol Biol. 2007;357:307-11. doi: 10.1385/1-59745-214-9:307. PMID: 17172696. https://doi.org/10.1385/1-59745-214-9:307

Maguire PB, Belton O, O’Donoghue N, Austin S, Coppinger J. Platelet-Endothelial Interactions from Part II – Endothelial Cell as Input-Output Device. Publishes online by Cambridge University Press
https://doi.org/10.1017/CBO9780511546198.065

Coppinger J, Fitzgerald DJ, Maguire PB (2007). Isolation of the Platelet Releasate. In: Vivanco, F. (eds) Cardiovascular Proteomics. Methods in Molecular Biology™, vol 357. Humana Press. https://doi.org/10.1385/1-59745-214-9:307

2005

Kelly P, Maguire PB, Bennett M, Fitzgerald DJ, Edwards RJ, Thiede B, Treumann A, Collins JK, O’Sullivan GC, Shanahan F, Dunne C. Correlation of probiotic Lactobacillus salivarius growth phase with its cell wall-associated proteome. FEMS Microbiol Lett. 2005 Nov 1;252(1):153-9. doi: 10.1016/j.femsle.2005.08.051. Epub 2005 Sep 19. PMID: 16214296. https://doi.org/10.1016/j.femsle.2005.08.051

2004

Maguire PB. Platelet proteomics: identification of potential therapeutic targets. Pathophysiol Haemost Thromb. 2003 Sep-2004 Dec;33(5-6):481-6. doi: 10.1159/000083849. PMID: 15692264. https://doi.org/10.1159/000083849

Maguire PB, Moran N, Cagney G, Fitzgerald DJ. Application of proteomics to the study of platelet regulatory mechanisms. Trends Cardiovasc Med. 2004 Aug;14(6):207-20. doi: 10.1016/j.tcm.2004.06.001. PMID: 15451512. https://doi.org/10.1016/j.tcm.2004.06.001

Coppinger JA, Cagney G, Toomey S, Kislinger T, Belton O, McRedmond JP, Cahill DJ, Emili A, Fitzgerald DJ, Maguire PB. Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions. Blood. 2004 Mar 15;103(6):2096-104. doi: 10.1182/blood-2003-08-2804. Epub 2003 Nov 20. PMID: 14630798. https://doi.org/10.1182/blood-2003-08-2804

2002

Maguire PB, Wynne KJ, Harney DF, O’Donoghue NM, Stephens G, Fitzgerald DJ. Identification of the phosphotyrosine proteome from thrombin activated platelets. Proteomics. 2002 Jun;2(6):642-8. doi: 10.1002/1615-9861(200206)2:6<642::AID-PROT642>3.0.CO;2-I. PMID: 12112843. https://doi.org/10.1002/1615-9861(200206)2:6<642::aid-prot642>3.0.co;2-i